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As in the United States, drivers in Bolivia use the right side of the road. While the use of seatbelts is not mandatory in the country, it is highly recommended that you buckle up before starting your engine. If your car breaks down (or in case of emergencies), you should call 911 for assistance, unless your provider has other specific instructions included in your rental agreement.
One must be 18 years of age to rent a car in Bolivia; however, most car companies insist on being at least 21 years old and having a valid driver’s license for no less than 12 months (e.g., Hertz). Many rental agencies in Bolivia will apply a young person’s surcharge, around 104-345 BOB (15-50 USD) per day if you are under the age of 25, but there are some who do not (e.g., Economy).
Bolivia has very good prices for diesel fuel, around 3.72 BOB (0.54 USD) per liter and approx. 2.05 USD per gallon. Likewise, a liter of petrol costs about 3.74 BOB (0.54 USD) and about 2.08 USD per gallon. Petrol stations are fewer outside of cities and big towns, so you should fill up the tank before taking off to explore.
If you rent a car in Bolivia, then you should know that the speed limit within city areas is 40 km/h (about 25 mph), which increases to 70 km/h (43 mph) in rural areas and 80 km/h (about 50 mph) if you are traveling along highways. Be advised that speed limits are generally ignored by the locals, so be cautious when exploring the country by car.